We included physiological studies, publications on relevant guidelines, meta-analysis, randomized clinical trials, and cohort studies. Methods: A systematic evaluation of relevant literature in Medline was conducted. Objectives: To describe a practical approach based on the literature regarding clinically important aspects of calcium and vitamin D supplementation. Robert Y. van der Velde 1 *, Jacobus R. B. J. Brouwers 2, Piet P. Geusens 3, 4, Willem F. Lems 5 and Joop P. W. van den Bergh 1, 3, 4ġDepartment of Internal Medicine, VieCuri Medical Centre for North Limburg, Venlo, The Netherlands 2Department of Geriatric Medicine, Expertise Centre for Pharmacotherapy in the Elderly, Ephor-UMC Utrecht, The Netherlands 3Department of Rheumatology, CAPHRI, Maastricht UMC, Maastricht, The Netherlands 4Biomedical Research Centre, University of Hasselt, Diepenbeek, Belgium 5Department of Rheumatology, VU Medical Centre, Amsterdam, The Netherlandsīackground: Calcium and vitamin D play an essential role in bone metabolism but deficiency and/or inadequate intake are common. REVIEW ARTICLE Calcium and vitamin D supplementation: state of the art for daily practice Calcium and vitamin D supplementation: state of the art for daily practice
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